Prevalence and risk factors of proteinuria in patients with type 2 diabetes mellitus

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Boonyong Jeerasuwannakul
Bundit Sawunyavisuth
Sittichai Khamsai
Kittisak Sawanyawisuth

Abstract

Type 2 diabetes mellitus (DM) is a common disease in clinical practice. Proteinuria or urine protein-tocreatinine ratio (UPCR) is an indicator for tubular biomarker for diabetic kidney disease. There is limited data on risk factors of proteinuria in patients with DM particularly in Thai or Asian populations. This study aimed to evaluate prevalence and risk factors of proteinuria in patients with type 2 DM in Thai population. This was a retrospective study conducted at Roi Et Hospital, Roi Et, Thailand. The study criteria were adult patients diagnosed as diabetes mellitus type 2 and treated at Diabetes Mellitus clinic, Roi Et Hospital for at least three months. The primary outcome of the study was presence of proteinuria of over 150 mg/g by UPCR. Factors predictive of proteinuria were computed by logistic regression analysis. During the study period, there were 299 patients met the study criteria. Of those, 92 patients (30.77%) had proteinuria. There were eight factors eligible for multivariate logistic regression analysis for proteinuria. Of those, only fasting plasma glucose (FPG) was independently associated with proteinuria with adjusted odds ratio of 1.009 (95% CI 1.004, 1.0156). The FPG of 136 mg/dL or over had sensitivity of 80.43%. In conclusion, prevalence of proteinuria in patients with type 2 DM was 30.77% in provincial hospital setting. FPG may be associated with presence of proteinuria. A cut off point of FPG of 136 mg/dL had good sensitivity as a predictor of proteinuria in patients with type 2 DM.

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References

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