Predictors for sarcopenia in biliary tract cancer patients
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Abstract
Here, we report the clinical predictors for sarcopenia. Sarcopenia is a common condition in patients with cancer and is associated with treatment toxicity and poorer outcomes. However, there are limited data available on its differential clinical features in biliary tract cancer (BTC) patients with and without sarcopenia. Our primary analysis showed that decreased muscle mass was associated with shorter overall survival. This was a retrospective analysis of a prospective cohort of BTC patients who received chemotherapy between January 2016 and December 2017. Factors associated with sarcopenia were examined using uni- and multivariate logistic regression. During the study period, a total of 71 participants, including 45 with sarcopenia (63%) and 26 without sarcopenia (27%), were included. Four significant factors differed between those with and without sarcopenia including age (61.9 vs 55.3 years), the proportion of male patients (87% vs 65%), body mass index (20.6 vs 23.2 kg/m2), and skeletal muscle density (53.9 vs 59.2 HU). There were two independent predictors for sarcopenia in BTC patients: body mass index (BMI) and skeletal muscle density, with adjusted odds ratios (95% confidence interval) of 0.683 (0.530, 0.880) and 0.811 (0.700-0.944), respectively. Our study concludes that low body mass index and low skeletal muscle density on computed tomography (CT) imaging are suggestive of sarcopenia in biliary tract cancer patients.
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