Development and evaluation of curcumin nano emulsion in moisturizer for antiaging
Article Sidebar
Main Article Content
Abstract
In this study, an attempt was made to prepare a curcumin nano moisturizer. Curcumin is a powerful antioxidant that neutralizes free radicals and reactive oxygen species. (ROS). Various formulations were prepared by utilizing a pseudo-ternary phase diagram and an appropriate surfactant and co-surfactant mixture (Smix), with olive oil serving as the oil phase. Curcumin and excipients were found to be compatible in FTIR investigations, and droplet dispersion analysis was performed on all formulations. The formulation F3 was found to be optimal, with particle size and zeta potential of mean n=3, 506.30.43 nm, and -31.10.04 mV, respectively. It was characterized and evaluated for viscosity, spreadability, pH, thermodynamic stability studies, robustness to dilution ratio, percent transmittance, drug diffusion studies, and free radical scavenging assay by using DPPH, F3 formulation inhibited 88% of free radicals, which was more than the positive control, ascorbic acid, and it suppressed ROS generation. Short-term stability studies on optimized curcumin nano moisturizer show that it can be stored in a well-closed wide-mouth container for two months at 40±2°C and 75% RH. As a result, the prepared nano moisturizer showed to be a potential anti-aging cosmeceutical candidate.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Igarashi T, Nishino K, Nayar SK. The appearance of human skin. Foundations and Trends® in Computer Graphics and Vision. 2007;3(1):1-95.
Poljsak B, Dahmane R. Free radicals and extrinsic skin aging. Dermatol Res & Practice. 2012;13(5):125-136.
Raha S, Robinson BH. Mitochondria, oxygen free radicals, disease and ageing. Trends in Biochem Sci. 2000;25(10):502-508.
Pandel R, Poljsak B, Godic A, Dahmane R. Skin photo aging and the role of antioxidants and its prevention. ISRN dermatology. 2013;12(8):325-340.
Pubchem [Internet]. Maryland: The Government; c2004-2023 [cited 2023 April 08]. Curcumin. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Curcumin.
Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, et al. Nano emulsion: concepts, development and applications in drug delivery. J Controlled Release. 2017;252:28-49.
Malik P, Ameta RK, Singh M. Physicochemical study of curcumin in oil driven nano emulsions with surfactants. J Mole Liquids. 2016;220:604-622.
Hussain A, Samad A, Nazish I, Ahmed FJ. Nanocarrier-based topical drug delivery for an antifungal drug. Drug Deve Ind Pharm. 2014;40(4):527-541.
Rowe RC, Sheskey P, Quinn M. Handbook of pharmaceutical excipients. 1st ed. London: Pharmaceutical Press; 2009.
Kharat M, Skrzynski M, Decker EA, McClements DJ. Enhancement of chemical stability of curcumin-enriched oil-in-water emulsions: Impact of antioxidant type and concentration. Food Chem. 2020;19:1266-1283.
Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, et al. Formation and stability of oil-in-water Nano emulsions containing rice bran oil: in vitro and in vivo assessments. J Nano Biotech. 2011;9(1):44-56.
Mahdi ES, Noor AM, Sakeena MH, Abdullah GZ, Abdulkarim MF, Sattar MA. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nano emulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int J Nanomed. 2011;6:24-39.
Hussain A, Samad A, Nazish I, Ahmed FJ. Nanocarrier-based topical drug delivery for an antifungal drug. Drug Deve Ind Pharm. 2014;40(4):527-541.
El-Leithy ES, Makky AM, Khattab AM, Hussein DG. Optimization of nutraceutical coenzyme Q10 nanoemulsion with improved skin permeability and anti-wrinkle efficiency. Drug Deve Ind Pharm. 2018;44(2):316-328.
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin antiaging strategies. Dermatol Endocrinol. 2012;4(3):308-319.
Elsheikh MA, Elnaggar YS, Gohar EY, Abdallah OY. Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal. Int Nanomed. 2012;7:39-57.
Elnaggar YS, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharma. 2009;380(1):133-141.
Pathan IB, Setty CM. Enhancement of transdermal delivery of tamoxifen citrate using nanoemulsion vehicle. Int J Pharm Tech Res. 2011;3(1):287-297.
Rachmawati H, Budiputra DK, Mauludin R. Curcumin nanoemulsion for transdermal application: formulation and evaluation. Drug Deve Ind Pharm. 2014;90(5):1-7.
Mahdi ES, Noor AM, Sakeena MH, Abdullah GZ, Abdul Karim MF, Sattar MA. Formulation and in- vitro release evaluation of newly synthesized palm kernel oil esters based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int J Nanomed. 2011;6:24-39.
Sari TP, Mann B, Kumar R, Singh RR, Sharma R, Bhardwaj M, et al. Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocolloids. 2015;43:540-546.
Gupta RK, Gupta D, Mann S. Phytochemical nutritional and antioxidant activity evaluation of seeds of jackfruit. Int J Pharm Bio Sci 2011;2(4):336-355.
Gupta S, Chavhan S, Sawant KK. Self-nanoemulsifying drug delivery system for adefovir dipivoxil: design, characterization, in vitro and ex vivo evaluation. Colloids Surfaces A Physicochem Engg Aspects. 2011;392(1):145-155.
Uthaman S, Maya S, Jayakumar R, Cho-Su C. Carbohydrates based nanogels as drug and gene delivery system. J Nanosci Nanotechnol.2014;14:624-636.
Artigas AM, Perez LY, Belloso MO. Curcumin-loaded nano emulsions stability as affected by the nature and concentration of surfactant. Food chemistry. 2018;266:466-474.
Marto J, Neves A, Gonçalves LM, Pinto P, Almeida C, Simoes S. Rice water: a traditional ingredient with anti-aging efficacy. Cosmetics. 2018;5(2):1-12.
Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, et al. Nanoemulsion: concepts, development and applications in drug delivery. J Controlled Release. 2017;252:28-49.
Hussain A, Samad A, Nazish I, Ahmed FJ. Nanocarrier-based topical drug delivery for an antifungal drug. Drug Deve Ind Pharm. 2014;40(4):527-541.
Mahdi ES, Noor AM, Sakeena MH, Abdullah GZ, Abdulkarim MF, Sattar MA. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int J Nanomed. 2011;6:24-39.
Ribeiro RC, Barreto SM, Ostrosky EA, Rocha-Filho PA, Verissimo LM, Ferrari M. Production and characterization of cosmetic nano emulsions containing opuntia ficusindica. Mill extract as moisturizing agent. Molecules. 2015;20(2):2492-509.