Study of novel self-assembled coordination nanoparticles from surfactants and gadolinium ion to stabilize curcumin in buffered solution

Abstract

In this study, we have reported novel coordination nanoparticles prepared by self-assembly of surfactants and gadolinium ion (Gd³⁺) to stabilize curcumin in buffer solution. Effects of various buffers including HEPES, MOPS, Tris and phosphate and various surfactants including SDS, CTAB and Triton X-100 towards the morphology and structural properties of the nanoparticles were investigated by FTIR spectroscopy, SEM, TEM and XRD techniques. From SEM and TEM images, the formation of coordination nanoparticles from Gd³⁺, SDS and HEPES namely GdSHshowed excellently uniform spherical nanoparticles. The particle size of GdSH nanoparticles measured by DLS technique is approximately 140.65  nm. Moreover, the encapsulation of curcumin in self-assembled coordination nanopariticles were prepared and then characterized by UV-visible, fluorescence spectrophotoscopy and infrared spectroscopy. The stability of curcumin was also examined by fluorescence spectrophotoscopy and the result showed the decrease of the normalized fluorescence intensity of curcumin incorporated in coordination nanoparticles was less 2-folds than that of dissolved in buffer solution at the same time. These results showed that the self-assembled coordination nanopariticles offered promising results in improving the stability of curcumin in buffer solution. Finally, this study would be beneficial to further development of stability of curcumin for biological tasks.