Hypoglycemic effect of Senna siamea (Lam.) leaf extract in rats (Thai)

Abstract

The hypoglycemic effect of ethanolic extract from Senna siamea leaves was studied in rats (weight 200-250 g). The results showed that within 1-5 hours, the extract at doses of 500 and 750 mg/kg bw. orally had significantly decreased blood glucose by 50.32 and 47.29 % per hour when compared with rats treated with insulin stimulating substance, glibenclamide (10 mg/kg bw.; P< 0.05). The anti-hyperglycemic effect was also studied by oral glucose tolerance test. It was found that extract at dose of 500 mg /kg. bw and glibenclamide inhibited an increase in blood glucose. This study concludes that Senna siamea leaf extract exhibits a hypoglycemic effect and antihyperglycemic effect in non-diabetic rats after induction of hyperglycemia with 2 g/kg bw. of glucose feeding.