Potential of clove oil on In Vitro antioxidant activity and factors affecting oil encapsulation efficiency in solid lipid particles

Abstract

Free radicals may cause dermal elastin and collagen damages leading to early wrinkle formation. Clove oil possesses a powerful antioxidant activity which might have a potential for anti-wrinkle cosmetics. The aims of this study were to investigate on antioxidant activity of clove oil by thiobarbituric acid reactive substances (TBARS) assay and 2,2-diphenyl-l-1-picrylhydrazyl (DPPH) test and study the characteristics of clove oil solid lipid particle (SLP) delivery system prepared by solvent emulsification diffusion method using 23 Full factorial design. The effects of 3 factors which were tween 80, benzyl alcohol and polyvinyl alcohol on characteristics of SLP including, particle size, Zeta potential and percent oil entrapment were investigated. Of the 8 tests formula, the maximal percentage of oil entrapment was up to 96.6%. Benzyl alcohol and tween 80 were significantly affected the particle size of SLP and their zeta potential.