Antibacterial activity of curcuminoids Against Staphylococcus aureus(Thai)

Abstract

The antibacterial activity of curcuminoids was tested against 45 clinical isolates of Staphylococcus aureus
(20 isolates of methicillin-resistant S. aureus ; MRSA and 25 isolates of methicillin-susceptible S. aureus; MSSA) by agar dilution method. The curcuminoids showed inhibitory effect against the MRSA andMSSA with the same level of MIC 90 (62.5μ g/ml). The combination of tetracycline or gentamicin with curcuminoids was also investigated. The results indicated that the activity of the combination was indifferent against MRSA and MSSA. Although the combination effect aginst MSSA of gentamicin and curcuminoids was indifferent against MRSA, the combination effect was synergism effect against MSSA. From the result of this study, the curcuminoids possesses anti-staphylococcal activity and curcuminoids-gentamicin exhibits synergism against some strains of MSSA.