Cadmium (Cd)-concentration and histopathological changes and metallothionien expression in the kidney of wild great bandicoots residing in a Cd-intoxicated area in Thailand
Article Sidebar
Published:
Apr 26, 2017
Keywords:
cadmium wild great bandicoot kidney light microscopy metallothionien expression weight-size subgrouping
Main Article Content
Abstract
The cadimium (Cd)-concentration and gene expression for metallothionien, an intrinsic Cd‑detoxifying protein, as well as its histopathology were examined in kidneys of wild greater bandicoot rats from Cd-contaminated and uncontaminated areas in Thailand. The Cd-concentration was greater in higher body-weight and sized from both the contaminated and uncontaminated areas. The Cd-concentration in large-sized animals from the contaminated area was the highest among all the specimens, while that in medium-sized animals from the contaminated area was higher than that in large-sized ones from the uncontaminated area. No significant differences in the Cd‑concentration in the specimen’s kidneys was noted between small-sized animals from the contaminated and uncontaminated areas. Histopathological changes such as necrosis, inflammatory cell infiltration and fibrosis, were more severe in the kidneys of animals with larger body sizes from the contaminated area. No significant differences in the expression of the gene for metallothionien were noted between kidneys of the animals from the contaminated and uncontaminated areas.
Article Details
How to Cite
Hipkaeo, W., Siriked, K., Sakulsak, N., Supanpaiboon, W., Cheunchoojit, S., & Kondo, H. (2017). Cadmium (Cd)-concentration and histopathological changes and metallothionien expression in the kidney of wild great bandicoots residing in a Cd-intoxicated area in Thailand. Asia-Pacific Journal of Science and Technology, 22(1), APST–22. https://doi.org/10.14456/apst.2017.1
Section
Research Articles
References
[1] Martelli, A., Rousselet, E., Dycke, C., Bouron, A., Moulis, J.M., 2006. Cadmium toxicity in animal cells by interference with essential metals. Biochimie 88, 1807-1814.
[2] Nordberg, G.F., Nogawa, K., Nordberg, M., Friberg, L.T., 2007. Chapter 23 - Cadmium. In: Gunnar FN, Bruce AF, Monica N, Lars T, FribergA2 -Gunnar F, Nordberg BAFMN, Lars TF, (Eds.) Handbook on the Toxicology of Metals. 3rd ed. Academic Press, Burlington.
[3] Godt, J., Scheidig, F., Grosse-Siestrup, C., Esche, V., Brandenburg, P., Reich, A., Groneberg, D.A., 2006. The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology 10, 1-22.
[4] Barbier, O., Jacquillet, G., Tauc, M., Cougnon, M., Poujeol, P., 2005. Effect of heavy metals on, and handling by, the kidney. Nephron Physiology 99, 105-110.
[5] Thevenod, F., 2003. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiology 93, 87-93.
[6] Klaassen, C.D., Liu, J., Choudhuri, S., 1999. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annual Review of Pharmacology and Toxicology 39, 267-294.
[7] Garrett, S.H., Somji, S., Todd, J.H., Sens, M.A., Sens, D.A., 1998. Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. Environmental Health Perspectives 106, 825-831.
[8] Bylander, J.E., Li, S.L., Sens, M.A., Sens, D.A., 1995. Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA. Toxicology Letters 76, 209-217.
[9] Lu, J., Jin, T., Nordberg, G., Nordberg, M., 2005. Metallothionein gene expression in peripheral lymphocytes and renal dysfunction in a population environmentally exposed to cadmium. Toxicology and Applied Pharmacology 206, 150-156.
[10] Swaddiwudhipong, W., Limpatanachote, P., Mahasakpan, P., Krintratun, S., Padungtod, C., 2007. Cadmium-exposed population in Mae Sot District, Tak Province: 1. Prevalence of high urinary cadmium levels in the adults. Journal of the Medical Association of Thailand 90, 143-148.
[11] Simmons, R.W., Pongsakul, P., Saiyasitpanich, D., Klinphoklap, S., 2005. Elevated levels of cadmium and zinc in paddy soils and elevated levels of cadmium in rice grain downstream of a zinc mineralized area in Thailand: implications for public health. Environmental Geochemistry and Health 27, 501-511.
[12] Zarcinas, B., Pongsakul, P., McLaughlin, M., Cozens, G., 2004. Heavy metals in soils and crops in Southeast Asia 2. Thailand. Environmental Geochemistry and Health 26, 359-371.
[13] Satarug, S., Haswell-Elkins, M.R., Moore, M.R., 2000. Safe levels of cadmium intake to prevent renal toxicity in human subjects. British Journal of Nutrition 84, 791-802.
[14] Boonsong, L., McNeely, J.A., Marshall, J.T., 1988. Mammals of Thailand. Association for the Conservation of Wildlife. Bangkok, Thailand, Kuruspha Ladprao Press.
[15] Sakagami, H., Suzuki, H., Kamata, A., Owada, Y., Fukunaga, K., Mayanagi, H., Kondo, H., 2006. Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain. Brain Research1093, 1-11.
[16] Hamada, T., Nakano, S., Iwai, S., Tanimoto, A., Ariyoshi, K., Koide, O., 1991. Pathological study on beagles after long-term oral administration of Cadmium. Toxicologic Pathology 19, 138-147.
[17] Jihen el, H., Imed, M., Fatima, H., Abdelhamid, K., 2008. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food and Chemical Toxicology 46, 3522-3527.
[18] Robbins, S.L., Kumar, V., Cotran, R.S., 2010. Robbins and Cotran pathologic basis of disease. Philadelphia, PA, Saunders/Elsevier.
[19] Salinska, A., Wlostowski, T., Zambrzycka, E., 2012. Effect of dietary cadmium and/or lead on histopathological changes in the kidneys and liver of bank voles Myodes glareolus kept in different group densities. Ecotoxicology 21, 2235-2243.
[20] Teeyakasem, W., Nishijo, M., Honda, R., Satarug, S., Swaddiwudhipong, W., Ruangyuttikarn, W., 2007. Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure. Toxicology Letters 169, 185-95.
[21] Satarug, S., Baker, J.R., Reilly, P.E., Moore, M.R., Williams, D.J., 2002. Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals. Archives of Environmental Health 57, 69-77.
[22] Swiergosz-Kowalewska, R., Bednarska, A., Callaghan, A., 2007. Expression of metallothionein genes I and II in bank vole Clethrionomys glareolus populations chronically exposed in situ to heavy metals. Environmental Science & Technology 41, 1032-1037.
[23] Percy, C.J., Brown, L., Power, D.A., Johnson, D.W., Gobe, G.C., 2009. Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mechanisms of Ageing and Development 130, 129-38.
[24] Akesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Strömberg, U., Skerfvin, S., 2005. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environmental Health Perspectives 113, 1627-1631.
[25] Hermesz, E., Abraham, M., Nemcsok, J., 2001. Tissue-specific expression of two metallothionein genes in common carp during cadmium exposure and temperature shock. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 128, 457-465.
[26] Geffard, A., Geffard, O., His, E., Amiard, J.-C., 2002. Relationships between metal bioaccumulation and metallothionein levels in larvae of Mytilus galloprovincialis exposed to contaminated estuarine sediment elutriate. Marine Ecology Progress Series 233, 131-142.
[27] Misra, R.R., Crance, K.A., Bare, R.M., Waalkes, M.P., 1997. Lack of correlation between the inducibility of metallothionein mRNA and metallothionein protein in cadmium-exposed rodents. Toxicology 117, 99-109.
[2] Nordberg, G.F., Nogawa, K., Nordberg, M., Friberg, L.T., 2007. Chapter 23 - Cadmium. In: Gunnar FN, Bruce AF, Monica N, Lars T, FribergA2 -Gunnar F, Nordberg BAFMN, Lars TF, (Eds.) Handbook on the Toxicology of Metals. 3rd ed. Academic Press, Burlington.
[3] Godt, J., Scheidig, F., Grosse-Siestrup, C., Esche, V., Brandenburg, P., Reich, A., Groneberg, D.A., 2006. The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology 10, 1-22.
[4] Barbier, O., Jacquillet, G., Tauc, M., Cougnon, M., Poujeol, P., 2005. Effect of heavy metals on, and handling by, the kidney. Nephron Physiology 99, 105-110.
[5] Thevenod, F., 2003. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiology 93, 87-93.
[6] Klaassen, C.D., Liu, J., Choudhuri, S., 1999. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annual Review of Pharmacology and Toxicology 39, 267-294.
[7] Garrett, S.H., Somji, S., Todd, J.H., Sens, M.A., Sens, D.A., 1998. Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. Environmental Health Perspectives 106, 825-831.
[8] Bylander, J.E., Li, S.L., Sens, M.A., Sens, D.A., 1995. Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA. Toxicology Letters 76, 209-217.
[9] Lu, J., Jin, T., Nordberg, G., Nordberg, M., 2005. Metallothionein gene expression in peripheral lymphocytes and renal dysfunction in a population environmentally exposed to cadmium. Toxicology and Applied Pharmacology 206, 150-156.
[10] Swaddiwudhipong, W., Limpatanachote, P., Mahasakpan, P., Krintratun, S., Padungtod, C., 2007. Cadmium-exposed population in Mae Sot District, Tak Province: 1. Prevalence of high urinary cadmium levels in the adults. Journal of the Medical Association of Thailand 90, 143-148.
[11] Simmons, R.W., Pongsakul, P., Saiyasitpanich, D., Klinphoklap, S., 2005. Elevated levels of cadmium and zinc in paddy soils and elevated levels of cadmium in rice grain downstream of a zinc mineralized area in Thailand: implications for public health. Environmental Geochemistry and Health 27, 501-511.
[12] Zarcinas, B., Pongsakul, P., McLaughlin, M., Cozens, G., 2004. Heavy metals in soils and crops in Southeast Asia 2. Thailand. Environmental Geochemistry and Health 26, 359-371.
[13] Satarug, S., Haswell-Elkins, M.R., Moore, M.R., 2000. Safe levels of cadmium intake to prevent renal toxicity in human subjects. British Journal of Nutrition 84, 791-802.
[14] Boonsong, L., McNeely, J.A., Marshall, J.T., 1988. Mammals of Thailand. Association for the Conservation of Wildlife. Bangkok, Thailand, Kuruspha Ladprao Press.
[15] Sakagami, H., Suzuki, H., Kamata, A., Owada, Y., Fukunaga, K., Mayanagi, H., Kondo, H., 2006. Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain. Brain Research1093, 1-11.
[16] Hamada, T., Nakano, S., Iwai, S., Tanimoto, A., Ariyoshi, K., Koide, O., 1991. Pathological study on beagles after long-term oral administration of Cadmium. Toxicologic Pathology 19, 138-147.
[17] Jihen el, H., Imed, M., Fatima, H., Abdelhamid, K., 2008. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food and Chemical Toxicology 46, 3522-3527.
[18] Robbins, S.L., Kumar, V., Cotran, R.S., 2010. Robbins and Cotran pathologic basis of disease. Philadelphia, PA, Saunders/Elsevier.
[19] Salinska, A., Wlostowski, T., Zambrzycka, E., 2012. Effect of dietary cadmium and/or lead on histopathological changes in the kidneys and liver of bank voles Myodes glareolus kept in different group densities. Ecotoxicology 21, 2235-2243.
[20] Teeyakasem, W., Nishijo, M., Honda, R., Satarug, S., Swaddiwudhipong, W., Ruangyuttikarn, W., 2007. Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure. Toxicology Letters 169, 185-95.
[21] Satarug, S., Baker, J.R., Reilly, P.E., Moore, M.R., Williams, D.J., 2002. Cadmium levels in the lung, liver, kidney cortex, and urine samples from Australians without occupational exposure to metals. Archives of Environmental Health 57, 69-77.
[22] Swiergosz-Kowalewska, R., Bednarska, A., Callaghan, A., 2007. Expression of metallothionein genes I and II in bank vole Clethrionomys glareolus populations chronically exposed in situ to heavy metals. Environmental Science & Technology 41, 1032-1037.
[23] Percy, C.J., Brown, L., Power, D.A., Johnson, D.W., Gobe, G.C., 2009. Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mechanisms of Ageing and Development 130, 129-38.
[24] Akesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Strömberg, U., Skerfvin, S., 2005. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environmental Health Perspectives 113, 1627-1631.
[25] Hermesz, E., Abraham, M., Nemcsok, J., 2001. Tissue-specific expression of two metallothionein genes in common carp during cadmium exposure and temperature shock. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 128, 457-465.
[26] Geffard, A., Geffard, O., His, E., Amiard, J.-C., 2002. Relationships between metal bioaccumulation and metallothionein levels in larvae of Mytilus galloprovincialis exposed to contaminated estuarine sediment elutriate. Marine Ecology Progress Series 233, 131-142.
[27] Misra, R.R., Crance, K.A., Bare, R.M., Waalkes, M.P., 1997. Lack of correlation between the inducibility of metallothionein mRNA and metallothionein protein in cadmium-exposed rodents. Toxicology 117, 99-109.