Effect of Apis Dorsata honey and honey sugars analogue on hematological and some biochemical parameters in albino rats model

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Sarfraz Ahmed
Siti Amrah Sulaiman
Nor Hayati Othman


Honey has been recognized for its wound-healing, anti-microbial, anti-oxidant, anti-diabetic and anticancer effects. This study was designed to examine the effect of daily oral administration of Malaysian Tualang honey (TH) and honey sugars analogue (HSA) namely fructose, glucose, maltose and sucrose in albino Sprague-Dawley (SD) rats model. Thirty nulliparous female rats were divided into three groups: Group 0 (negative control); Groups 1 and 2 received 1.0 g/kg body weight/day of TH and HSA respectively. After 120 days treatment, the rats were subjected to necropsy and blood samples were collected for analyses. The body weight, fasting blood glucose, haematological parameters and serum level expression of proteins such as Apaf-1, IFN-????, TNF-ɑ and E2 were determined. Results show that an increased body weight was observed as the treatment progressed over days (p˃0.05). TH and HSA showed an increasing effect on the level of haematological parameters such as red blood cells (RBC), haemoglobin (Hb), packed cell volume (PCV) (p˃0.05), lymphocytes, TWBC, RDW, eosinophils, monocytes and platelets (p˂0.05) compared to the non-treated negative control. HSA showed a slightly comparable effect to the negative control for fasting blood glucose level, while TH presented a slightly hypoglycemic effect (p˃0.05).  The treatments also showed an increasing effect on serum level of Apaf-1, IFN-????, TNF-ɑ and a reduced level for E2. In conclusion, daily supplementation of TH and HSA may modulate haematological and serological parameters.


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